个人简介

      熊小檍，副教授，硕士生导师。担任重庆市卒中后抑郁和精神障碍专业委员会委员、四川省科技青年联合会理事等学术任职。主要研究方向急性脑卒中（脑出血和脑梗死）脑损伤机制、针刺治疗的神经环路机制。获得国自然青年项目、四川省杰出青年科学基金、国家重点研发计划青年科学家项目（课题骨干）、重庆市“科技新星培育工程”等课题资助等多项课题资助，并参与国家杰出青年科学基金、国自然重点项目、973项目等多项课题研究。以第一/通讯作者（含共同）在Circulation、Prog Neurobiol等本领域高水平SCI期刊发表论文15篇，他引320余次，JCR 1区4篇，ESI高被引论文1篇。近年来主要研究成果有：1）揭示了脑出血后胶质细胞介导的炎症信号加重氧化性损伤导致神经元铁死亡的机理；2）阐明衰老脑出血过度炎症反应发生的表观遗传调控机制，并首次发现年轻血浆可能通过逆转表观遗传修饰显著减轻衰老脑出血脑损伤，为临床脑出血治疗提供了新思路新策略。获得全军优秀博士、硕士学位论文，张香桐神经科学优秀研究生论文奖、第十二届中国神经科学海报展优秀奖、重庆市“科技新星培育工程”资助对象、第三军医大学首届“学术海报展”一等奖、第三军医大学优秀博士毕业生等荣誉称号。

代表性成果

1. Xu R#, Gong C#, Duan C, Huang J, Yang G, Yuan J, Zhang Q, Xiong X*, Yang Q*. Age-Dependent Changes in the Plasma Proteome of Healthy Adults. J Nutr Health Aging. 2020.

2. Yang GQ #, Huang JC #, Yuan JJ, Zhang Q, Gon CX g, Chen Q, Xie Q, Xie LX, Chen R, Qiu ZM, Zhou K, Xu R, Jiang GH, Xiong XY *, Yang QW *. Prdx1 Reduces Intracerebral Hemorrhage-Induced Brain Injury via Targeting Inflammation- and Apoptosis-Related mRNA Stability. Front Neurosci. 2020, 14:181.

3. Huang J(#), Yang G(#), Xiong X(#), Wang M, Yuan J, Zhang Q, Gong C, Qiu Z, Meng Z, Xu R, Chen Q, Chen R, Xie L, Xie Q, Zi W, Jiang G, Zhou Y*, Yang Q*. Age-related CCL12 Aggravates Intracerebral Hemorrhage-induced Brain Injury via Recruitment of Macrophages and T Lymphocytes. Aging Dis. 2020

4. Yuan JJ(#), Xu R(#), Chen Q, Huang JC, Gong CX, Zhang Q, Yang QW*, Xiong XY*. Mfsd2a Is Not Involved in the Iron Metabolism. Ann Nutr Metab. 2020;76(1):83-85. DOI: 10.1159/000505588.

5. Yuan JJ(#), Zhang Q(#), Gong CX(#), Wang FX, Huang JC, Yang GQ, Liu L, Zhou K, Xu R, Chen Q, Zhou Y, Xiong XY*, Yang QW*. Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage. Biosci Rep. 2019; 39(5). pii: BSR20190537.

6. Xiong XY(#), Liu L, Yang QW(*). Refocusing neuroprotection in cerebral reperfusion era: new challenges and strategies. Front Neurol. 2018; 9:249.

7. Yang YR(#), Xiong XY(#), Liu J, Wu LR, Zhong Q, Zhou K, Meng ZY, Liu L, Wang FX, Gong QW, Liao MF, Duan CM, Li J, Yang MH, Zhang Q, Gong CX, Yang QW(*). Mfsd2a Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Inhibiting Vesicular Transcytosis. J Am Heart Assoc. 2017;6(7). pii: e005811.

8. Wang FX(#), Xiong XY (#), Zhong Q, Meng ZY, Yang H, Yang QW(*). Foxp3 exhibits antiepileptic effects in ictogenesis involved in TLR4 signaling. FASEB J. 2017;31(7):2948-2962.

9. Liu L(#), Xiong XY(#), Zhang Q, Fan XT (*), Yang QW (*). The Efficacy of Prophylactic Antibiotics on Post-Stroke Infections: An Updated Systematic Review and Meta-Analysis. Sci Rep. 2016; 6:36656.

10. Xiong XY(#), Liu L, Wang FX, Yang YR, Hao JW, Wang PF, Zhong Q, Zhou K, Xiong A, Zhu WY, Zhao T, Meng ZY, Wang YC, Gong QW, Liao MF, Wang J, Yang QW(*). TLR4/MyD88 mediated signaling of hepcidin expression causing brain iron accumulation, oxidative injury, and cognitive impairment after intracerebral hemorrhage. Circulation. 2016; 134:1025–1038.

11. Xiong XY(#), Liu L, Yang QW(*). Functions and Mechanisms of Microglia/Macrophages in Neuroinflammation and Neurogenesis after Stroke. Prog Neurobiol. 2016,142:23-44.

12. Xiong XY(#), Wang TG(#), Yang MH, Meng ZY, Yang QW(*), Wang FX(*). Interleukin-21 expression in hippocampal astrocytes is enhanced following kainic acid-induced seizures. Neurol Res. 2016, 38(2):151-7.

13. Xiong XY(#), Chen J(#), Zhu WY, Zhao T, Zhong Q, Zhou K, Meng ZY, Wang YC, Wang PF, Fang H, Yang QW(*). Serum hepcidin concentrations correlate with serum iron level and outcome in patients with intracerebral hemorrhage. Neurol Sci. 2015, 36(10):1843-1849.

14. Xiong XY(#), Yang QW(*). Rethinking the roles of inflammation in the intracerebral hemorrhage. Transl Stroke Res. 2015, 6(5):339-341.

15. Xiong XY(#), Wang J, Qian ZM, Yang QW(*). Iron and intracerebral hemorrhage: from mechanism to translation. Transl Stroke Res. 2014, 5(4):429-441.