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程永现教授

    
 
 
 

      程永现,博士、特聘教授、硕、博士生导师、德国洪堡学者、深圳大学药学院副院长(主持工作);现任世界中医药学会联合会中药化学分会常务理事、世界中医药学会联合会道地药材多维评价专业委员会常务理事等;目前还是Natural Products and Bioprospecting、“天然产物研究与开发”、“中国现代中药”编委;研究方向为中药药效物质;曾获得国家杰出青年科学基金、NSFC-云南联合基金重点项目、国家重点研发计划课题、“十二五”国家重大科技专项等。程永现教授长期从事中药科学原理与新药、健康产品转化工作,主要是在中医药理论和自然界仿生学启发下,运用“衷中参西”的方法围绕重大疾病和“未病”开展中药有效成分的发现与作用机制、中药配伍原理指导下的结构优化以及中药有效成分挖掘的方法学研究,形成了在中医治则治法指导下较为成熟的研究体系和鲜明的研究特色,其开拓的研究领域如灵芝杂萜化学、发扬光大的昆虫内源性非肽类活性小分子研究在国际上均处于领先地位;发表论文270余篇(SCI 196篇),其中17篇发表在Nature Index收录的Org Lett上。曾获云南省自然科学一等奖、广东省科技进步一等奖、中华医学科技一等奖、国家科技进步二等奖等。

 
 

1.Si-Si Zhu, Jia-Wang Liu, Yong-Ming Yan, Ying Liu, Zhuo Mao, Yong-Xian Cheng*. Terpenoids from Resina Commiphora Regulating Lipid Metabolism via Activating PPARα and CPT1 Expression. Organic Letters 2019, 22, 3428–3432.

2.Fu-Ying Qin, Hao-Xing Zhang, Qian-Qian Di, Yan Wang, Yong-Ming Yan, Wei-Lin Chen*, Yong-Xian Cheng*. Ganoderma cochlear metabolites as probes to identify a COX-2 active site and as in vitro and in vivo anti-inflammatory agents. Organic Letters 2020, doi.org/10.1021/acs.orglett.0c00452.

3.Yong-Ming Yan, Hao-Xing Zhang, Huan Liu, Yan Wang, Jin-Bo Wu, Yan-Peng Li, Yong-Xian Cheng*. (+/-)-Lucidumone, a COX-2 inhibitory caged fungal meroterpenoid from Ganoderma lucidum. Organic Letters 2019, 21, 8523–8527.

4.Lu Dong, Da-Peng Qin, Qian-Qian Di, Ying Liu, Wei-Lin Chen, Shu-Mei Wang, Yong-Xian Cheng*. Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition. Organic Chemistry Frontiers 2019, 6, 3825–3833.

5.Kai-Xin Liu, Yan-Xia Zhu, Yong-Ming Yan, Yue Zeng, Ya-Bing Jiao, Fu-Ying Qin, Jia-Wang Liu, Yuan-Yuan Zhang, Yong-Xian Cheng*. Discovery of Populusone, a Skeletal Stimulator of Umbilical Cord Mesenchymal Stem Cells from Populus euphratica Exudates. Organic Letters 2019, 21, 1837–1840.

6.Ying-Ying Song, Jin-Hua Miao, Fu-Ying Qin, Yong-Ming Yan, Jing Yang, Da-Peng Qin, Fan-Fan Hou*, Li-Li Zhou*, Yong-Xian Cheng*. Belamchinanes A-D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity Against Age-related Renal Fibrosis. Organic Letters 2018, 20, 5506–5509.

7.Jia-Wang Liu, Ying Liu, Yong-Ming Yan, Jing Yang, Xi-Feng Lu*, Yong-Xian Cheng*. Commiphoratones A and B, Two Sesquiterpene Dimers from Resina Commiphora. Organic Letters 2018, 20, 2220–2223.

8.Jia-Wang Liu, Ming-Yu Zhang, Yong-Ming Yan, Xiao-Yi Wei, Lu Dong, Yan-Xia Zhu*, and Yong-Xian Cheng*. Characterization of Sesquiterpene Dimers from Resina Commiphora that Promote Adipose-Derived Stem Cell Proliferation and Differentiation. The Journal of Organic Chemistry 2018, 83, 2725-2733.

9.Lu Dong, Li-Zhi Cheng, Yong-Ming Yan, Shu-Mei Wang, Yong-Xian Cheng*. Commiphoranes A-D, Carbon Skeletal Terpenoids from Resina commiphora. Organic Letters 2017, 19, 286–289.

10.Qi Luo, Zhu-Liang Yang, Yong-Ming Yan, Yong-Xian Cheng*. Ganotheaecolin A, a Neurotrophic Conjugated Ergosterol with a Naphtho[1,8-ef]azulene Scaffold from Ganoderma theaecolum. Organic Letters 2017, 19, 718–721.

11.Qi Luo, Xiao-Yi Wei, Jing Yang, Jin-Feng Luo, Rui Liang, Zheng-Chao Tu, Yong-Xian Cheng*. Spiro Meroterpenoids from Ganoderma applanatum. Journal of Natural Products 2017, 80, 61–70.

12.Jun Ai, Jing Nie, Jiang-Bo He, Qin Guo, Mei Li, Ying Lei, You-hua Liu, Zhan-Mei Zhou, Feng-Xin Zhu, Min Liang, Yong-Xian Cheng*, Fan-Fan Hou*. GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-induced Smad3 Phosphorylation. Journal of the American Society of Nephrology 2015, 26, 1827–1838.

13.Feng-Jiao Zhou, Yin Nian, Yong-Ming Yan, Ye Gong, Qi Luo, Yu Zhang, Bo Hou, Zhi-Li Zuo, Shu-Mei Wang, He-Hai Jiang, Jian Yang*, Yong-Xian Cheng*. Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear. Organic Letters 2015, 17, 3082–3085.

14.Qi Luo, Lei Tian, Lei Di, Yong-Ming Yan, Xiao-Yi Wei, Xin-Fang Wang, and Yong-Xian Cheng*. (±)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Potent Smad3 Phosphorylation Inhibition from Ganoderma sinensis. Organic Letters 2015, 17, 1565–1568.

15.Qi Luo, Lei Di, Wei-Feng Dai, Qing Lu, Yong-Ming Yan, Zhu-Liang Yang, Rong-Tao Li, and Yong-Xian Cheng*. Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum that Displays Potent Antifibrotic Activity. Organic Letters 2015, 17, 1110?1113.

    
 

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